Journal article

Long-term development of white matter fibre density and morphology up to 13 years after preterm birth: A fixel-based analysis

Claire E Kelly, Deanne K Thompson, Sila Genc, Jian Chen, Joseph YM Yang, Chris Adamson, Richard Beare, Marc L Seal, Lex W Doyle, Jeanie LY Cheong, Peter J Anderson



BACKGROUND: It is well documented that infants born very preterm (VP) are at risk of brain injury and altered brain development in the neonatal period, however there is a lack of long-term, longitudinal studies on the effects of VP birth on white matter development over childhood. Most previous studies were based on voxel-averaged, non-fibre-specific diffusion magnetic resonance imaging (MRI) measures, such as fractional anisotropy. In contrast, the novel diffusion MRI analysis framework, fixel-based analysis (FBA), enables whole-brain analysis of microstructural and macrostructural properties of individual fibre populations at a sub-voxel level. We applied FBA to investigate the long-term i..

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Awarded by Australian National Health and Medical Research Council [NHMRC]

Awarded by Royal Children's Hospital Foundation

Funding Acknowledgements

This research was supported by the Australian National Health and Medical Research Council [NHMRC; Centre for Research Excellence 546519, 1060733 and 1153176; Project Grant 237117, 491209 and 1066555; Senior Research Fellowship 1081288 to PJA; Investigator Grant 1176077 to PJA; Career Development Fellowship 1085754 to DKT and 1141354 to JLYC, and; Early Career Fellowship 1012236 to DKT], the Murdoch Children's Research Institute, the Royal Children's Hospital, the Royal Children's Hospital Foundation [RCH1000 to JYMY], the Department of Paediatrics at the University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program.