Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo; Stephanie Allison-Logan; Fatemeh Karimi; Nicholas Jun-An Chan; Wenlian Qiu; Wei Duan; Neil M O'Brien-Simpson; Greg G Qiao

Journal article

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao

Chemical Society Reviews | Royal Society of Chemistry | Published : 2020

DOI: 10.1039/c9cs00738e

Abstract

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with rational monomer composition can direct architecture, self-assembly and chemical behavior, ultimately guiding the choice of appropriate application within the biomedical field. This review focuses on the applications of polypeptides alongside the synthetic advances in the ring opening polymerization of α-amino acid N-carboxyanhydrides achieved in the past five years. Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the w..

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University of Melbourne Researchers

Neil O'Brien-Simpson Author

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Grants

Awarded by Australian Research Council (ARC)

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by Cancer Council Victoria

Funding Acknowledgements

This work was generously supported by the Australian Government Research Training Program Scholarship, the Melbourne International Engagement Award and the Melbourne International Research Scholarships. GGQ acknowledges the supports of the Australian Research Council (ARC)’s Discovery Project Grants (DP160101312, DP170104321), and the Australian National Health and Medical Research Council (NHMRC)’s Project Grant (APP1142472). NMOS is the recipient of NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284), and Australian Dental Research Funding in antimicrobial materials and research is supported by the Centre for Oral Health Research at The Melbourne Dental School. ARM wishes to thank Matthew D. Biviano for assistance.