Journal article

Exploratory study of association between blood immune markers and cognitive symptom severity in major depressive disorder: Stratification by body mass index status

Celia Fourrier, Emma Sampson, Hikaru Hori, K Oliver Schubert, Scott Clark, Natalie T Mills, Bernhard T Baune

Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

BACKGROUND: A subset of patients with Major Depressive Disorder (MDD) have shown differences relative to healthy controls in blood inflammatory and immune markers. Meanwhile, MDD and comorbid obesity appear to present with distinct biological and symptom characteristics, categorised as "atypical" or "immunometabolic" depression, although the relevant underlying biological mechanisms are still uncertain. Therefore, this exploratory study aimed to better characterise the relationship between peripheral blood immune markers and symptoms of MDD, as well as the extent to which body mass index (BMI) may alter this relationship. METHODS: Linear regression analyses were performed between selected ba..

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University of Melbourne Researchers