Journal article

Moraxella catarrhalisphase-variable loci show differences in expression during conditions relevant to disease

Aimee Tan, Luke V Blakeway, undefined Taha, Yuedong Yang, Yaoqi Zhou, John M Atack, Ian R Peak, Kate L Seib

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

Moraxella catarrhalis is a human-adapted, opportunistic bacterial pathogen of the respiratory mucosa. Although asymptomatic colonization of the nasopharynx is common, M. catarrhalis can ascend into the middle ear, where it is a prevalent causative agent of otitis media in children, or enter the lower respiratory tract, where it is associated with acute exacerbations of chronic obstructive pulmonary disease in adults. Phase variation is the high frequency, random, reversible switching of gene expression that allows bacteria to adapt to different host microenvironments and evade host defences, and is most commonly mediated by simple DNA sequence repeats. Bioinformatic analysis of five closed M..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) [Career Development Fellowship to KLS; Project Grant 1099279 to KLS, JMA], the Garnett Passe and Rodney Williams Memorial Foundation [Fellowship to AT and Grant in Aid Supplementation to KLS and JMA], and an Australian Government Research Training Program Scholarship to LVB. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. https://www.nhmrc.gov.au/funding https://gprwmf.org.au/https://www.education.gov.au/research-training-program