Journal article
Biomarkers of asthma relapse and lung function decline in adults with spontaneous asthma remission: A population-based cohort study
DJ Tan, CJ Lodge, EH Walters, AJ Lowe, DS Bui, G Bowatte, R Kandane-Rathnayake, FM Aldakheel, B Erbas, GS Hamilton, PS Thomas, M Hew, MLK Tang, MJ Abramson, JL Perret, SC Dharmage
Allergy European Journal of Allergy and Clinical Immunology | WILEY | Published : 2023
DOI: 10.1111/all.15566
Abstract
Background: The extent to which biomarkers of asthma activity persist in spontaneous asthma remission and whether such markers are associated with future respiratory outcomes remained unclear. We investigated the association between sub-clinical inflammation in adults with spontaneous asthma remission and future asthma relapse and lung function decline. Methods: The Tasmanian Longitudinal Health Study is a population-based cohort (n = 8583). Biomarkers of systemic inflammation were measured on participants at age 45, and latent profile analysis was used to identify cytokine profiles. Bronchial hyperresponsiveness (BHR) and nitric oxide products in exhaled breath condensate (EBC NOx) were mea..
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Funding Acknowledgements
National Health and Medical Research Council; University of Melbourne; Clifford Craig Foundation; Victorian, Queensland and Tasmanian Asthma Foundations; Royal Hobart Hospital Research Foundation; Helen MacPherson Smith Trust; GlaxoSmithKline