Journal article

Quantifying Response to Nutrition Therapy During Critical Illness: Implications for Clinical Practice and Research? A Narrative Review

Kate Fetterplace, Emma J Ridley, Lisa Beach, Yasmine Ali Abdelhamid, Jeffrey J Presneill, Christopher M MacIsaac, Adam M Deane

Journal of Parenteral and Enteral Nutrition | WILEY | Published : 2020


Critical illness causes substantial muscle loss that adversely impacts recovery and health related quality of life. Treatments are therefore needed that reduce mortality and/or improve the quality of survivorship. The purpose of this review is to describe both patient centered and surrogate outcomes that quantify responses to nutrition therapy in critically ill patients. The use of these outcomes in randomized clinical trials will be described, and the strengths and limitations of these outcomes detailed. Outcomes used to quantify the response of nutrition therapy must have a plausible mechanistic relationship to nutrition therapy, and either be an accepted measure for the quality of survivo..

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