Journal article

Adjunctive perampanel and myoclonic and absence seizures: Post hoc analysis of data from study 332 in patients with idiopathic generalized epilepsy

Christian Brandt, Robert T Wechsler, Terence J O'Brien, Anna Patten, Manoj Malhotra, Leock Y Ngo, Bernhard J Steinhoff

Seizure: European Journal of Epilepsy | W B SAUNDERS CO LTD | Published : 2020


PURPOSE: This post hoc analysis assessed the effects of adjunctive perampanel on myoclonic and absence seizure outcomes in patients (aged ≥12 years) with idiopathic generalized epilepsy (IGE) and generalized tonic-clonic seizures during the double-blind (up to 8 mg/day) and open-label extension (OLEx; up to 12 mg/day) phases of Study 332. METHODS: Patients experiencing myoclonic and/or absence seizures during study baseline were included. Assessments for myoclonic and absence seizures included: median percent change in seizure frequency, number of seizure days and seizure-free days (all per 28 days), 50 % and 75 % responder rates, seizure-freedom rates, seizure worsening, and monitoring of t..

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Funding Acknowledgements

This study was funded by Eisai Inc., who contributed to the design and conduct of the study, as well as the management, analysis and interpretation of the data. Medical writing support, under the direction of the authors, was provided by Rebecca Furmston, PhD, and Lisa Moore, PhD, of CMC AFFINITY, McCann Health Medical Communications, funded by Eisai Inc., in accordance with Good Publication Practice (GPP3) guidelines.