Journal article

Bone Measures by Dual-Energy X-Ray Absorptiometry and Peripheral Quantitative Computed Tomography in Young Women With Type 1 Diabetes Mellitus

Hongyuan Jiang, Dale L Robinson, Alison Nankervis, Suzanne M Garland, Emma T Callegari, Sarah Price, Peter VS Lee, John D Wark



Understanding bone fragility in young adult females with type 1 diabetes mellitus (T1DM) is of great clinical importance since the high fracture risk in this population remains unexplained. This study aimed to investigate bone health in young adult T1DM females by comparing relevant variables determined by dual-energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) at the tibia and pQCT-based finite element analysis (pQCT-FEA) between T1DM subjects (n = 21) and age-, height- and weight-matched controls (n = 63). Tibial trabecular density (lower by 7.1%; 228.8 ± 33.6 vs 246.4 ± 31.8 mg/cm3, p = 0.02) and cortical thickness (lower by 7.3%; 3.8 ± 0.5 vs 4.1 ± 0.5 ..

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Awarded by Australian National Health and Medical Research Council (NHMRC) program

Awarded by NHMRC

Awarded by China Scholarship Council

Funding Acknowledgements

The authors thank all subjects for their participation in this study. We acknowledge Associate Professor Christopher J Yates for helpful discussion on the background information and analysis of this study, Dr Ashwini Kale for performing DXA and pQCT scans, and Ms Heather Robinson and Ms Adele Rivers for collecting data from many participants. The YFHI study was funded by the Australian National Health and Medical Research Council (NHMRC) program grant 568971. The SafeD study was funded by NHMRC project grant APP1049065. HJ is funded with a joint PhD scholarship by China Scholarship Council (CSC201608240003) and the University of Melbourne, Australia. This study was also supported by a grantinaid from the Novo Nordisk Regional Grant Scheme to Associate Professor Alison Nankervis.