Journal article
A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder
SA Sullivan, D Kounali, M Cannon, AS David, PC Fletcher, P Holmans, H Jones, PB Jones, DEJ Linden, G Lewis, MJ Owen, M O'Donovan, A Rammos, A Thompson, D Wolke, J Heron, S Zammit
American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2020
Abstract
Objective: The authors investigated the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in the general population and examined prediction of psychotic disorder. Methods: This was a population-based cohort study using the semistructured Psychosis-Like Symptoms Interview at ages 12, 18, and 24 (N=7,900 with any data). Incidence rates were estimated using flexible parametric modeling, and positive predictive values (PPVs), sensitivity, specificity, and area under the curve were estimated for prediction. Results: The incidence rate of psychotic experiences increased between ages 13 and 24, peaking during late adolescence. Of 3,866 participants inter..
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Awarded by NIHR Imperial Biomedical Research Centre
Funding Acknowledgements
The U.K. Medical Research Council and Wellcome (grant ref. 102215/2/13/2) and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children. The study was funded by Medical Research Council grant MR/M006727/1.Dr. Zammit acknowledges support from the NIHR Biomedical Research Centre (BRC) at University Hospitals Bristol NHS Foundation Trust and the University of Bristol; Dr. David and Dr. Lewis from the NIHR BRC at University College London Hospital; Dr. P.B. Jones from the NIHR CLAHRC East of England, NIHR PGfAR RP-PG-0616-20003 (TYPPEX) and the Wellcome Trust Neuroscience in Psychiatry Network (095844/Z/11/Z); Dr. Fletcher from the Wellcome Trust (206368/Z/17/Z) and the Bernard Wolfe Health Neuroscience Fund; and Dr. Cannon from a European Research Council Consolidator Award (iHEAR 724809).Dr. Fletcher serves as a consultant for Ninja Theory Ltd., a video game design studio. Dr. Linden has received royalties from Oxford University Press and Springer Nature and editorial fees from Elsevier. Dr. Owen and Dr. O'Donovan receive support from a research grant from Takeda. The other authors report no financial relationships with commercial interests.