Journal article

Exercise and GLUT4

Marcelo Flores-Opazo, Sean L McGee, Mark Hargreaves

Exercise and Sport Sciences Reviews | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

University of Melbourne Researchers


Funding Acknowledgements

We acknowledge the many researchers who have worked on exercise and GLUT4 and apologize that we have not been able to cite all published work. The original work of the authors was supported by the Diabetes Australia Research Program and the National Health and Medical Research Council of Australia. Marcelo Flores-Opazo was supported by the Becas Chile scholarship program of CONYCIT, Chile.