Journal article

Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences

Kit Melissa Larsen, Ilvana Dzafic, Hayley Darke, Holly Pertile, Olivia Carter, Suresh Sundram, Marta Garrido

Schizophrenia Research | ELSEVIER | Published : 2020

Abstract

BACKGROUND: The ability to generate a precise internal model of statistical regularities is impaired in schizophrenia. Predictive coding accounts of schizophrenia suggest that psychotic symptoms may be explained by a failure to build precise beliefs or a model of the world. The precision of this model may vary with context. For example, in a noisy environment the model will be more imprecise compared to a model built in an environment with lower noise. However compelling, this idea has not yet been empirically studied in schizophrenia. METHODS: In this study, 62 participants engaged in a stochastic mismatch negativity paradigm with high and low precision. We included inpatients with a schizo..

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Grants

Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre)


Awarded by University of Queensland Fellowship


Awarded by Australian Research Council


Funding Acknowledgements

This work was funded by the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007), a University of Queensland Fellowship (2016000071), and a Women's Academic Fund Maternity funding from Queensland Government, to MIG. OC is supported by the Australian Research Council FFT40100807.