Journal article

Targeting the centromedian thalamic nucleus for deep brain stimulation

Aaron EL Warren, Linda Dalic, Wesley Thevathasan, Annie Roten, Kristian Bulluss, John Archer

Cold Spring Harbor Laboratory | Published : 2019

Abstract

Objectives : Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox-Gastaut syndrome (LGS). We aimed to improve neurosurgical targeting of the CM by (i) developing a structural MRI approach for CM visualisation, (ii) identifying the CM's neurophysiological characteristics, and (iii) mapping connectivity from CM-DBS sites using functional MRI (fMRI). Methods: Nineteen patients with LGS (mean age=28 years) underwent pre-surgical 3 tesla MRI using magnetisation-prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fMRI sequences; 16 proceeded to bilateral CM-DBS implantation..

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University of Melbourne Researchers