Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Wayland Yeung, Diane Coursier, Richard W Birkinshaw, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Isabelle S Lucet, James D Chalmers, Wayne M Patrick, Natarajan Kannan, Emma J Petrie, Peter E Czabotar, James M Murphy
Nature Communications | NATURE PUBLISHING GROUP | Published : 2020
Awarded by National Health and Medical Research Council
Awarded by NIH
We thank staff at the Australian Synchrotron MX beamline for assistance with data collection. This research was undertaken in part using the MX2 crystallography beamline at the Australian Synchrotron, Victoria, Australia, and made use of the ACRF Detector. We gratefully acknowledge Clive Stone (Te Iwi o Ngatiwai) for enabling the tuatara MLKL sequence to be shared ahead of its publication. We acknowledge scholarship support for K.A.D. and S.E.G. (Australian Government Research Training Program Stipend Scholarships), L.-Y.L. (Melbourne Research Scholarship) and K.A.D. (AINSE PGRA scholarship). We are grateful to the National Health and Medical Research Council for fellowship (PEC, 1079700; JMM, 1105754, 1172929), grant (1057905; 1124735) and infrastructure (IRIISS 9000587) support; Australian Cancer Research Foundation; and the Victorian Government Operational Infrastructure Support scheme. Funding for N.K. from NIH (5R01GM114409) is acknowledged.