Journal article

MR1: a multi-faceted metabolite sensor for T cell activation

Hamish EG McWilliam, Jose A Villadangos

Current Opinion in Immunology | CURRENT BIOLOGY LTD | Published : 2020

Abstract

The major histocompatibility complex class I-related molecule MR1 captures and presents small metabolites to MR1-restricted T cells including Mucosal Associated Invariant T (MAIT) cells. The first MR1 ligands discovered were intermediates of microbial riboflavin synthesis, antigens presented to alert inflammatory MAIT cells to bacterial infection. Recent advances have expanded the range of MR1 ligands to include extracellular metabolites released by the commensal microbiome, and yet undefined antigens presented by cancer cells to mediate MR1-dependent anti-tumor activity. MR1 thus exhibits a multifaceted ability to display a diverse range of ligands for immune surveillance in a variety of co..

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Grants

Awarded by NHMRC


Awarded by Australian Research Council (ARC), Discovery Early Career Researcher Award


Funding Acknowledgements

J.A.V. is supported by an NHMRC Principal Research Fellowship (1154502) and Program Grant (1113293). H.E.G.M. is supported by an Australian Research Council (ARC), Discovery Early Career Researcher Award (DE170100575) and the AMP Tomorrow Fund. The authors declare that they have no competing financial interests.