Journal article

Progressive and accelerated weight and body fat loss in Parkinson's disease: A three-year prospective longitudinal study

Voon Wei Yong, Yan Jing Tan, Yi-De Ng, Xing Yan Choo, Kavita Sugumaran, Karuthan Chinna, Mohammad Nazri Md Shah, Raja Rizal Azman Raja Aman, Foong Ming Moy, Norlisah Mohd Ramli, Mathis Grossmann, Shen-Yang Lim, Ai Huey Tan

Parkinsonism & Related Disorders | ELSEVIER SCI LTD | Published : 2020

Abstract

INTRODUCTION: Although weight loss is common in Parkinson's disease (PD), longitudinal studies assessing weight and body composition changes are limited. METHODS: In this three-year longitudinal study, 125 subjects (77 PD patients and 48 spousal/sibling controls) underwent clinical, biochemical and body composition assessments using dual-energy X-ray absorptiometry. RESULTS: Patients were older than controls (65.6 ± 8.9 vs. 62.6 ± 7.1, P = 0.049), with no significant differences in gender, comorbidities, dietary intake and physical activity. Clinically significant weight loss (≥5% from baseline weight) was recorded in 41.6% of patients, with a doubling of cases (6.5 to 13.0%) classified as u..

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University of Melbourne Researchers

Grants

Awarded by University of Malaya Faculty Research Grant


Awarded by University of Malaya Parkinson's Disease and Movement Disorder Research Program


Funding Acknowledgements

This work was supported by the University of Malaya Faculty Research Grant (GPF018C-2018) and University of Malaya Parkinson's Disease and Movement Disorder Research Program (PV035-2017). These funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.