Journal article
Progesterone to prevent miscarriage in women with early pregnancy bleeding: The PRISM RCT
A Coomarasamy, HM Harb, AJ Devall, V Cheed, TE Roberts, I Goranitis, CB Ogwulu, HM Williams, ID Gallos, A Eapen, JP Daniels, A Ahmed, R Bender-Atik, K Bhatia, C Bottomley, J Brewin, M Choudhary, F Crosfill, S Deb, WC Duncan Show all
Health Technology Assessment | Published : 2020
DOI: 10.3310/hta24330
Abstract
Background: Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue a pregnancy in women with early pregnancy bleeding, which is a symptom that is strongly associated with miscarriage. Objectives: (1) To assess the effects of vaginal micronised progesterone in women with vaginal bleeding in the first 12 weeks of pregnancy. (2) To evaluate the cost-effectiveness of progesterone in women with early pregnancy bleeding. Design: A multicentre, double-blind, placebo-controlled, randomised trial of progesterone in women with early pregnancy vaginal bleeding. Setting: A total of 48 hospitals in the UK. Participants: Women aged 16–39..
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