Tumor in 3D: In Vitro Complex Cellular Models to Improve Nano-drugs Cancer Therapy
Soraia Fernandes, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri, Giancarlo Forte
Current Medicinal Chemistry | BENTHAM SCIENCE PUBL LTD | Published : 2020
Nanodrugs represent novel solutions to reshuffle repurposed drugs for cancer therapy. They might offer different therapeutic options by combining targeted drug delivery and imaging in unique platforms. Such nanomaterials are deemed to overcome the limitations of currently available treatments, ultimately improving patients' life quality. However, despite these promises being made for over three decades, the poor clinical translation of nanoparticle-based therapies calls for deeper in vitro and in vivo investigations. Translational issues arise very early during the development of nanodrugs, where complex and more reliable cell models are often replaced by easily accessible and convenient 2D ..View full abstract
Awarded by European Regional Development Fund-Project MAGNET
Awarded by European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant
Awarded by European Union's horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant
The work has been supported by the European Regional Development Fund-Project MAGNET (Number CZ.02.1.01/0.0/0.0/15 003/0000492) and by the European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement no. 690901. Marco Cassani is an iCARE-2 fellow and the project leading to these results has received funding from AIRC and the European Union's horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 800924.