Journal article

Effect of Testosterone Treatment for Delayed Puberty in Duchenne Muscular Dystrophy

Samantha Lai-Ka Lee, Angelina Lim, Craig Munns, Peter J Simm, Margaret Zacharin

HORMONE RESEARCH IN PAEDIATRICS | KARGER | Published : 2020

Abstract

OBJECTIVE: To evaluate the impact of pubertal induction with testosterone on bone health, body composition, and motor function in boys with Duchenne muscular dystrophy (DMD) receiving long-term glucocorticoid. STUDY DESIGN: A retrospective, observational, pre-post study investigating the impact of testosterone therapy on bone mass accrual, vertebral fracture incidence, body composition, motor function, and quality of life in boys with DMD. All those boys aged ≥14 years, on chronic steroid therapy, who had delayed puberty, and were receiving oral testosterone or oral and then transitioned to intramuscular testosterone, to complete virilization, were included. Prior/concomitant zoledronic acid..

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