Journal article

Partial deletion of p75(NTR)in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neuronsin vivo

Zuoheng Qin, David G Gonsalvez, Rhiannon J Wood, Fatemeh Daemi, Sangwon Yoo, Jason J Ivanusic, Elizabeth J Coulson, Simon S Murray, Junhua Xiao

JOURNAL OF NEUROSCIENCE RESEARCH | WILEY | Published : 2020

Abstract

The p75 neurotrophin receptor (p75NTR ) is required for maintaining peripheral sensory neuron survival and function; however, the underlying cellular mechanism remains unclear. The general view is that expression of p75NTR by the neuron itself is required for maintaining sensory neuron survival and myelination in the peripheral nervous system (PNS). Adopting a neuronal-specific conditional knockout strategy, we demonstrate the partial depletion of p75NTR in neurons exerts little influence upon maintaining sensory neuron survival and peripheral nerve myelination in health and after demyelinating neuropathy. Our data show that the density and total number of dorsal root ganglion (DRG) neurons ..

View full abstract