Journal article

Ageing in human parturition: impetus of the gestation clock in the decidua

Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Bill Kalionis

Biology of Reproduction | OXFORD UNIV PRESS INC | Published : 2020


Despite sharing many common features, the relationship between ageing and parturition remains poorly understood. The decidua is a specialized lining of endometrial tissue, which develops in preparation for pregnancy. The structure and location of the decidua support its role as the physical scaffold for the growing embryo and placenta, and thus, it is vital to sustain pregnancy. Approaching term, the physical support properties of the decidua are naturally weakened to permit parturition. In this review, we hypothesize that the natural weakening of decidual tissue at parturition is promoted by the ageing process. Studies of the ageing-related functional and molecular changes in the decidua at..

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Funding Acknowledgements

This work was funded by the Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, Parkville, Victoria, Australia and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Victoria, Australia, and an Australia Awards Scholarships from the Department of Foreign Affairs and Trade (Australia) to JCW.