Journal article

Functional changes in decidual mesenchymal stem/stromal cells are associated with spontaneous onset of labour

Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Maria Kokkinos, Patrick F James, Shaun P Brennecke, Bill Kalionis

Molecular Human Reproduction | Oxford University Press (OUP) | Published : 2020

Abstract

Ageing and parturition share common pathways, but their relationship remains poorly understood. Decidual cells undergo ageing as parturition approaches term, and these age-related changes may trigger labour. Mesenchymal stem/stromal cells (MSCs) are the predominant stem cell type in the decidua. Stem cell exhaustion is a hallmark of ageing, and thus ageing of decidual MSCs (DMSCs) may contribute to the functional changes in decidual tissue required for term spontaneous labour. Here, we determine whether DMSCs from patients undergoing spontaneous onset of labour (SOL-DMSCs) show evidence of ageing-related functional changes compared with those from patients not in labour (NIL-DMSCs), undergoi..

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Grants

Funding Acknowledgements

This work was funded by the Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, the Department of Obstetrics and Gynaecology of the University of Melbourne, and an Australia Awards Scholarships from the Department of Foreign Affairs and Trade (Australia) to J.C.W.