Journal article

Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults

Oana A Tatucu-Babet, Adrienne Forsyth, Emma Owen, Diana Navarro-Perez, Jessica Radcliffe, Devin Benheim, Himasha Mendis, Markandeya Jois, Catherine Itsiopoulos, Audrey C Tierney



The association between intestinal permeability (IP) and body composition remains unclear. The gold standard differential sugar-absorption test is arduous to complete, with zonulin being increasingly used as an independent biomarker of IP. This pilot study aimed to explore the association between small IP, zonulin concentrations, and body composition in healthy adults. The urinary lactulose-rhamnose ratio was used to measure small IP. Serum zonulin, lipopolysaccharide (LPS) and high-sensitivity C-reactive protein (hs-CRP) were analyzed in serum. Body composition was measured using dual-energy X-ray absorptiometry and anthropometric measurements were collected. In total, 34 participants were ..

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Funding Acknowledgements

This work was supported by The Australasian Society of Parenteral and Enteral Nutrition Substantive Project Grant. Oana Tatucu-Babet was supported by an Australian Government Research Training Program Scholarship and a La Trobe University School of Allied Health Writing Up Award. The authors have no conflicts of interest to disclose.