Journal article

DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure

Chris R Bain, Mark Ziemann, Antony Kaspi, Abdul Waheed Khan, Rachael Taylor, Hugh Trahair, Ishant Khurana, Harikrishnan Kaipananickal, Sophie Wallace, Assam El-Osta, Paul S Myles, Kiymet Bozaoglu



AIMS: Natriuretic peptides are useful for diagnosis and prognostication of heart failure of any cause. Now, research aims to discover novel biomarkers that will more specifically define the heart failure phenotype. DNA methylation plays a critical role in the development of cardiovascular disease with the potential to predict fundamental pathogenic processes. There is a lack of data relating DNA methylation in heart failure that specifically focuses on patients with severe multi-vessel coronary artery disease. To begin to address this, we conducted a pilot study uniquely exploring the utility of powerful whole-genome methyl-binding domain-capture sequencing in a cohort of cardiac surgery pat..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This research was funded by a services support grant through the Baker IDI Heart and Diabetes Institute. C.R.B. is supported by the Australian and New Zealand College of Anaesthetists (ANZCA). K.B. is supported by an E. H. Flack Fellowship. Additional infrastructure funding to the Baker Heart and Diabetes Institute and Murdoch Children's Research Institute was provided by the Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme and the Victorian Government's Operational Infrastructure Support Program. A.E.-O. is a National Health and Medical Research Council (NHMRC) Senior Research Fellow (1154650 and 0526681). The funding bodies had no role in the design, analysis, interpretation, or reporting of results.