Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants
Allison L Hicks, Stephen M Kissler, Tatum D Mortimer, Kevin C Ma, George Taiaroa, Melinda Ashcroft, Deborah A Williamson, Marc Lipsitch, Yonatan H Grad
eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020
Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays infer resistance based on known genetic markers, their utility will wane with the emergence of novel resistance. Maintenance of these diagnostics will therefore require surveillance to ensure early detection of novel resistance variants, but efficient strategies to do so remain undefined. We evaluate the efficiency of targeted sampling approaches informed by patient and pathogen characteristics in detecting antibiotic resistance and diagnostic escape variants in Neisseria gonorrhoeae, a pathogen associated with a high b..View full abstract
Awarded by National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Allergy and Infectious Diseases (NIAID) R01AI132606 Yonatan H GradThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.