Journal article

Fiber-Specific Changes in White Matter Microstructure in Individuals With X-Linked Auditory Neuropathy

Julien Zanin, Thijs Dhollander, Gary Rance, Lan Yu, Lan Lan, Hongyang Wang, Xin Lou, Alan Connelly, Bryony Nayagam, Qiuju Wang



OBJECTIVES: Auditory neuropathy (AN) is the term used to describe a group of hearing disorders, in which the hearing impairment occurs as a result of abnormal auditory nerve function. While our understanding of this condition has advanced significantly over recent years, the ability to determine the site of lesion and the extent of dysfunction in affected individuals remains a challenge. To this end, we investigated potential axonal degeneration in the white matter tracts of the brainstem in individuals with X-linked AN. We hypothesized that individuals with X-linked AN would show focal degeneration within the VIII nerve and/or auditory brainstem tracts, and the degree of degeneration would ..

View full abstract


Awarded by National Natural Science Foundation of China

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

The authors acknowledge the financial support of the HEARing CRC, established under the Cooperative Research Centres (CRC) Program. The CRC Program supports industry-led end-user-driven research collaborations to address the major challenges facing Australia. BAN is supported by a Research Fellowship from the Garnett Passe and Rodney Williams Memorial Foundation. We are grateful to the National Natural Science Foundation of China (Major Project No. 81830028 and No. 81530032 to Q. J. W.), National Health and Medical Research Council (NHMRC: GNZT1023372, BAN) of Australia, and the Victorian Government's Operational Infrastructure Support Program for their support. The project also received funding from the University of Melbourne School of Health Science International Collaboration grant (awarded to G. R. and Q. J. W.).