Journal article

Review of Burden, Clinical Definitions, and Management of COVID-19 Cases

Laura McArthur, Dhanasekaran Sakthivel, Ricardo Ataide, Felicia Chan, Jack S Richards, Charles A Narh

American Journal of Tropical Medicine and Hygiene | AMER SOC TROP MED & HYGIENE | Published : 2020


Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019 (COVID-19), its clinical manifestations, and treatment options continues to evolve at an unparalleled pace. This review sought to summarize the key literature regarding transmission, case definitions, clinical management, and the burden of COVID-19. Our review of the literature showed that SARS-CoV-2 was mainly transmitted via inhalation of respiratory droplets containing the virus and had a mean incubation period of 4-6 days. The commonly reported symptoms were fever (75.3% ± 18.7%) and cough (62.6% ± 17.7%) across the spectrum of clinical disease-mild, moderate, severe, and critical, but with the disease ph..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (APP1161076 to J. S. R.). Burnet Institute received funding from the NHMRC Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support Scheme.