Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at similar to 65%V?O2peakin endurance trained men
Glenn K McConell, Glenn D Wadley, Kieran Le Plastrier, Kelly C Linden
JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2020
KEY POINTS: AMP-activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. However, we previously showed that, although AMPK activity increases by 8-10-fold during ∼120 min of exercise at ∼65% V ̇ O 2 peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study). In a cross-sectional study, we show that there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V ̇ O 2 peak in endurance-trained individuals. These findings indicate that AMPK is not an important regulator of exercise metabolism during 120 min of exercise at ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by a grant from the National Health and Medical Research Council (NHMRC) of Australia (GKM: 237002).