Journal article

Exploring human trainability: Design and rationale of Studies of Twin Responses to Understand Exercise as a Therapy (STRUETH) study

Channa E Marsh, Hannah J Thomas, Louise H Naylor, Katrina J Scurrah, Daniel J Green

Contemporary Clinical Trials Communications | ELSEVIER INC | Published : 2020

Abstract

Background: Exercise confers myriad health benefits and physical inactivity is a modifiable risk factor for many non-communicable chronic diseases. However, individual responsiveness to guideline-based exercise programs is idiosyncratic for health and fitness outcomes. It is not known whether the response of individuals to distinct exercise modalities tend to be concordant or whether there is a genetic contribution to variation in exercise responsiveness. Methods/design: Healthy, young adult (16-40yrs) monozygotic (MZ) and dizygotic (DZ) twin pairs were recruited and randomly assigned to 3 months of endurance or resistance exercise training. Twin pairs trained together. After 3 months of tra..

View full abstract

Grants

Awarded by National Health and Medical Research Council Principal Research Fellowship


Awarded by Centre of Research Excellence Grant from the National Health and Medical Research Council, Australia


Funding Acknowledgements

Professor Green is supported by a National Health and Medical Research Council Principal Research Fellowship (APP1080914).This research was facilitated through access to Twins Research Australia, a national resource. Dr. Scurrah and Twins Research Australia are supported by a Centre of Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council, Australia.Exercise and Sport Science Australia (ESSA) Clinical Exercise Physiology Research Grant.