Journal article

Intraoral human herpes viruses detectable by PCR in majority of patients

Tami Yap, Shuan Khor, Jung Seo Kim, Jaeyoung Kim, Sung Yun Kim, Johannes S Kern, Raymond Martyres, George Varigos, Hiu Tat Chan, Michael J McCullough, Melissa L Thomas, Laura Scardamaglia

Oral Diseases | John Wiley and Sons | Published : 2021

Abstract

Objectives To identify factors which influence the intraoral prevalence of human herpes viruses (HHVs) using mucosal swabs, saliva samples and qPCR analysis. Methodology In this cross-sectional observational study, matched saliva and oral swabs were collected from a total of 115 subjects: 70 immunocompetent subjects with no mucosal abnormalities, 22 with mucosal abnormalities and 23 therapeutically immunocompromised individuals. Extracted DNA was analysed by multiplex qPCR for detection and quantification of HHVs 1–6. Results At least one human herpes virus was detected in 77.1% of immunocompetent individuals with no mucosal abnormalities, with EBV the most commonly detected at 61.4%. HHV-..

View full abstract