Journal article

Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews

Kevin M Trentino, Shannon L Farmer, Michael F Leahy, Frank M Sanfilippo, James P Isbister, Rhonda Mayberry, Axel Hofmann, Aryeh Shander, Craig French, Kevin Murray

BMC Medicine | BMC | Published : 2020

Abstract

BACKGROUND: There are no overviews of systematic reviews investigating haemoglobin thresholds for transfusion. This is important as the literature on transfusion thresholds has grown considerably in recent years. Our aim was to synthesise evidence from systematic reviews and meta-analyses of the effects of restrictive and liberal transfusion strategies on mortality. METHODS: This was a systematic review of systematic reviews (overview). We searched MEDLINE, Embase, Web of Science Core Collection, PubMed, Google Scholar, and the Joanna Briggs Institute EBP Database, from 2008 to 2018. We included systematic reviews and meta-analyses of randomised controlled trials comparing mortality in patie..

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University of Melbourne Researchers