Journal article

Traceable Peptidic Ligands that Target Ghrelin Receptors

Mengjie Liu, John Wade, Mohammed Akhter Hossain

Current Protein and Peptide Science | BENTHAM SCIENCE PUBL LTD | Published : 2020

Abstract

Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide's signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.

Grants

Awarded by NHMRC (Australia)


Awarded by NHMRC


Funding Acknowledgements

This research was partly funded by NHMRC (Australia) project grants (1163310, 1023321 and 1023078) to M.A.H, J.D.W. J.D.W. is an NHMRC Principal Research Fellow (1117483). Studies at the FNI were supported by the Victorian Governments Operational Infrastructure Support Program.