Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo
Gustavo Duque, Christopher Vidal, Wei Li, Ahmed Al Saedi, Mamdouh Khalil, Chai K Lim, Damian E Myers, Gilles J Guillemin
Journal of Bone and Mineral Research | WILEY | Published : 2020
Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescribed osteoporosis drugs have led to the investigation of new and safer treatments with novel mechanisms of action. Picolinic acid (PIC), a catabolite of tryptophan, induces in vitro osteogenic differentiation of mesenchymal stem cells. Here we demonstrate that PIC has an anabolic effect on bone in vivo by increasing bone formation, bone mass, and bone strength in normal and ovariectomized C57BL/6 mice. Activation of the osteogenic pathways triggered this osteoanabolic response without any cross-related effects on mineral absorption or calciotropic hormones. Because..View full abstract
This study was supported by a Commercial Development & Industry Partnerships (CDIP) grant from Sydnovate (The University of Sydney) and seed grants from the Nepean Medical Research Foundation and the Australian Institute for Musculoskeletal Science (AIMSS) to CV, AAS, and GD. CV was funded by a grant from the Rebecca L. Cooper Foundation. GJG is funded by grants from the Australian National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), and Macquarie University. The authors thank Prof Nicholas Hunt from the Kolling Institute (Sydney, Australia) for his scientific advice and Dr Sara Vogrin for her assistance with the statistical analyses.