Journal article

Staphylococcus aureusinduces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

Maiken Mellergaard, Rikke Illum Hogh, Astrid Lund, Blanca Irene Aldana, Romain Guerillot, Sofie Hedlund Moller, Ashleigh S Hayes, Nafsika Panagiotopoulou, Zofija Frimand, Stine Dam Jepsen, Camilla Hartmann Friis Hansen, Lars Andresen, Anders Rhod Larsen, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden, Helle S Waagepetersen, Dorte Frees, Soren Skov

JOURNAL OF BIOLOGICAL CHEMISTRY | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2020

Abstract

Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The pathogenicity and establishment of S. aureus infections are tightly linked to its ability to modulate host immunity. Persistent infections are often associated with mutant staphylococcal strains that have decreased susceptibility to antibiotics; however, little is known about how these mutations influence bacterial interaction with the host immune system. Here, we discovered that clinical S. aureus isolates activate human monocytes, leading to cell-surface expression of immune stimulatory natural killer group 2D (NKG2D) ligands on the monocytes. We found that expression of the NKG2D ligand ULBP2 (UL16-bi..

View full abstract

Grants

Awarded by University of Copenhagen Faculty of Health and Medical Sciences


Awarded by Else and Mogens Wedell Wedellsborg Foundation


Awarded by Danish Council for Independent Research Grant


Awarded by Novo Nordisk Foundation


Funding Acknowledgements

This work was supported by Ph.D. Scholarship A3507 from the University of Copenhagen Faculty of Health and Medical Sciences (to M. M.), Else and Mogens Wedell Wedellsborg Foundation Grant 3A-17-1 (to M. M.), Danish Council for Independent Research Grant DFF-6111-00499 (to S. S.), and Novo Nordisk Foundation Grant NNF15CC0018346 (to S. S.).