Journal article

Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults?

Xianwen Shang, Allison M Hodge, Wei Peng, Mingguang He, Lei Zhang

Cancers | MDPI | Published : 2020

Abstract

Data on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45-64 years from the 45 and Up Study who were free of cancer, depression, and anxiety at baseline (2006-2009). The incidence of cancer, mental disorders, and multimorbidity (concurrent cancer and mental disorders) was identified using claim databases during follow-up until 31 December 2016. During a nine-year follow-up, the cumulative incidence of cancer, mental disorders, and multimorbidity was 8.8%, 17.4%, and 2.2%, respectively. Participants with cancer were 3.41 times more likely to develop mental disorders, while individuals with mental disorders were 3...

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Grants

Awarded by Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China


Awarded by National Natural Science Foundation of China


Awarded by Outstanding Young Scholars Funding


Awarded by Xi'an Jiaotong University Basic Research and Profession Grant


Awarded by Epidemiology modeling and risk assessment


Awarded by Xi'an Jiaotong University Young Talent Support Grant


Funding Acknowledgements

This specific project was funded by the Australia China Research Accelerator Program at Centre for Eye Research Australia. Professor Mingguang He is also supported by the Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China (81420108008). The funders were not involved in the research and preparation of the article, including study design; collection, analysis, and interpretation of data; writing of the article; or in the decision to submit it for publication. Professor Lei Zhang is also supported by the National Natural Science Foundation of China (Grant number: 81950410639); Outstanding Young Scholars Funding (Grant number: 3111500001), Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032), Epidemiology modeling and risk assessment (Grant number: 20200344), and Xi'an Jiaotong University Young Talent Support Grant (Grant number: YX6J004).