Journal article

Examining the added value of microperimetry and low luminance deficit for predicting progression in age-related macular degeneration

Zhichao Wu, Chi D Luu, Lauren Ab Hodgson, Emily Caruso, Fred K Chen, Usha Chakravarthy, Jennifer J Arnold, Wilson J Heriot, Jim Runciman, Robyn H Guymer

British Journal of Ophthalmology | BMJ PUBLISHING GROUP | Published : 2021


PURPOSE: To examine the added predictive value of microperimetric sensitivity and low luminance deficit (LLD; difference between photopic and low luminance visual acuity (VA)) to information from colour fundus photography (CFP) for progression to late age-related macular degeneration (AMD) in individuals with bilateral large drusen. METHODS: 140 participants with bilateral large drusen underwent baseline microperimetry testing, VA measurements and CFP. They were then reviewed at 6-monthly intervals to 36 months, to determine late AMD progression. Microperimetry pointwise sensitivity SD (PSD), LLD and the presence of pigmentary abnormalities on CFPs were determined. Predictive models based on..

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Awarded by National Health & Medical Research Council of Australia

Funding Acknowledgements

This study was supported by National Health & Medical Research Council of Australia (project grant no.: APP1027624 (RHG and CDL), and fellowship grant no.: GNT1103013 (RHG), APP1104985 (ZW), APP1054712 (FKC) and APP1142962 (FKC)) and BUPA Health Foundation (Australia) (RHG and CDL). CERA receives operational infrastructure support from the Victorian Government. The web-based Research Electronic Data Capture (REDCap) application and open-source platform OpenClinica allowed secure electronic data capture. The study is sponsored by the Centre for Eye Research Australia (CERA), an independent medical research institute and a not-for-profit company.