Examining the added value of microperimetry and low luminance deficit for predicting progression in age-related macular degeneration
Zhichao Wu, Chi D Luu, Lauren Ab Hodgson, Emily Caruso, Fred K Chen, Usha Chakravarthy, Jennifer J Arnold, Wilson J Heriot, Jim Runciman, Robyn H Guymer
British Journal of Ophthalmology | BMJ PUBLISHING GROUP | Published : 2021
PURPOSE: To examine the added predictive value of microperimetric sensitivity and low luminance deficit (LLD; difference between photopic and low luminance visual acuity (VA)) to information from colour fundus photography (CFP) for progression to late age-related macular degeneration (AMD) in individuals with bilateral large drusen. METHODS: 140 participants with bilateral large drusen underwent baseline microperimetry testing, VA measurements and CFP. They were then reviewed at 6-monthly intervals to 36 months, to determine late AMD progression. Microperimetry pointwise sensitivity SD (PSD), LLD and the presence of pigmentary abnormalities on CFPs were determined. Predictive models based on..View full abstract
Awarded by National Health & Medical Research Council of Australia
This study was supported by National Health & Medical Research Council of Australia (project grant no.: APP1027624 (RHG and CDL), and fellowship grant no.: GNT1103013 (RHG), APP1104985 (ZW), APP1054712 (FKC) and APP1142962 (FKC)) and BUPA Health Foundation (Australia) (RHG and CDL). CERA receives operational infrastructure support from the Victorian Government. The web-based Research Electronic Data Capture (REDCap) application and open-source platform OpenClinica allowed secure electronic data capture. The study is sponsored by the Centre for Eye Research Australia (CERA), an independent medical research institute and a not-for-profit company.