Influence of Protein Glycosylation onCampylobacter fetusPhysiology
Justin Duma, Harald Nothaft, Danielle Weaver, Christopher Fodor, Bernadette Beadle, Dennis Linton, Stephane L Benoit, Nichollas E Scott, Robert J Maier, Christine M Szymanski
Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2020
Campylobacter fetus is commonly associated with venereal disease and abortions in cattle and sheep, and can also cause intestinal or systemic infections in humans that are immunocompromised, elderly, or exposed to infected livestock. It is also believed that C. fetus infection can result from the consumption or handling of contaminated food products, but C. fetus is rarely detected in food since isolation methods are not suited for its detection and the physiology of the organism makes culturing difficult. In the related species, Campylobacter jejuni, the ability to colonize the host has been linked to N-linked protein glycosylation with quantitative proteomics demonstrating that glycosylati..View full abstract
Awarded by National Institute of General Medical Sciences Training Grant
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by Overseas (Biomedical) Fellowship
JD was previously supported by the Alberta Glycomics Centre and subsequently the National Institute of General Medical Sciences Training Grant Award Number T32GM107004. NS was supported by the National Health and Medical Research Council of Australia (NHMRC) project grant (APP1100164) and by an Overseas (Biomedical) Fellowship (APP1037373). SB and RM received support from the University of Georgia Foundation. CS was an Alberta Innovates Strategic Chair in Bacterial Glycomics. DW was supported by a Society for Applied Microbiology Studentship.