Journal article

Comparative Genomics ofAcinetobacter baumanniiClinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes

Nilma C Leal, Tulio L Campos, Antonio M Rezende, Cassia Docena, Carina L Mendes-Marques, Felipe L de Sa Cavalcanti, Gabriel L Wallau, Igor V Rocha, Carmelita LB Cavalcanti, Dyana L Veras, Lilian R Alves, Mariana Andrade-Figueiredo, Maria P Silva de Barros, Alzira M Paiva de Almeida, Marcia M Camargo de Morais, Tereza C Leal-Balbino, Danilo E Xavier, Osvaldo P de-Melo-Neto



Acinetobacter baumannii is an opportunistic bacterial pathogen infecting immunocompromised patients and has gained attention worldwide due to its increased antimicrobial resistance. Here, we report a comparative whole-genome sequencing and analysis coupled with an assessment of antibiotic resistance of 46 Acinetobacter strains (45 A. baumannii plus one Acinetobacter nosocomialis) originated from five hospitals from the city of Recife, Brazil, between 2010 and 2014. An average of 3,809 genes were identified per genome, although only 2,006 genes were single copy orthologs or core genes conserved across all sequenced strains, with an average of 42 new genes found per strain. We evaluated geneti..

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University of Melbourne Researchers


Awarded by PROEP/FACEPE/Fiocruz

Funding Acknowledgements

This work was mainly supported by institutional funding from the Oswaldo Cruz Foundation (Fiocruz, Brazil). NL also received financial support from PROEP/FACEPE/Fiocruz (APQ1628-2.12/15). CM-M was funded by a PNPD/CAPES/PPGBBS institutional grant. Studentships and fellowships to the graduate students and post-doctoral fellows were granted by the Ministry of Education and the Pernambuco state funding agencies, Capes and FACEPE, respectively.