Journal article

Low Oxygen Stress During Early Development Influences Regulation of Hypoxia-Response Genes in Farmed Atlantic Salmon (Salmo salar)

Tara Kelly, Hanne Johnsen, Erik Burgerhout, Helge Tveiten, Tina Thesslund, Oivind Andersen, Nicholas Robinson

G3: Genes, Genomes, Genetics | GENETICS SOCIETY AMERICA | Published : 2020

Abstract

Survival and growth of developing salmonids are negatively affected by low oxygen levels within gravel nests in natural streams, and hypoxic stress is often experienced by farmed Atlantic salmon (Salmo salar) within hatcheries. Exposure to hypoxia during early development may have long-lasting effects by altering epigenetic marks and gene expression in oxygen regulatory pathways. Here, we examine the transcriptomic response to low dissolved oxygen (DO) in post-hatch salmon reared continuously in 30%, 60% or 100% DO from fertilization until start of feeding. RNA sequencing revealed multiple differentially expressed genes, including oxygen transporting hemoglobin embryonic α subunit (hbae) and..

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University of Melbourne Researchers

Grants

Awarded by Norwegian Institute of Food, Fisheries and Aquaculture (Nofima) Strategic Project - Research Council of Norway


Funding Acknowledgements

We would like to thank Tor H. Evensen (Nofima AS) for his technical assistance during the experiment. This work was supported by the Norwegian Institute of Food, Fisheries and Aquaculture (Nofima) Strategic Project 11881, granted by the Research Council of Norway.