Perspectives on neuroinflammation contributing to chronic cough
Alexandria K Driessen, Anna-Claire Devlin, Fionnuala T Lundy, S Lorraine Martin, Gerard P Sergeant, Stuart B Mazzone, Lorcan P McGarvey
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2020
Chronic cough can be a troublesome clinical problem. Current thinking is that increased activity and/or enhanced sensitivity of the peripheral and central neural pathways mediates chronic cough via processes similar to those associated with the development of chronic pain. While inflammation is widely thought to be involved in the development of chronic cough, the true mechanisms causing altered neural activity and sensitisation remain largely unknown. In this back-to-basics perspective article we explore evidence that inflammation in chronic cough may, at least in part, involve neuroinflammation orchestrated by glial cells of the nervous system. We summarise the extensive evidence for the r..View full abstract
This work was part of the BREATH project by the European Union under the Interreg VA Health and Life Science Programme. The views and opinions expressed in this paper do not necessarily reflect those of the European Commission or the Special European Union Programmes Body.