Journal article

Combined Isoflurane-Remifentanil Anaesthesia Permits Resting-State fMRI in Children with Severe Epilepsy and Intellectual Disability

Aaron EL Warren, Andrew Davidson, Simon J Vogrin, A Simon Harvey, Catherine Bailey, Linda J Dalic, David F Abbott, John S Archer

Brain Topography | SPRINGER | Published : 2020


Head motion is a significant barrier to functional MRI (fMRI) in patients who are unable to tolerate awake scanning, including young children or those with cognitive and behavioural impairments. General anaesthesia minimises motion and ensures patient comfort, however the optimal anaesthesia regimen for fMRI in the paediatric setting is unknown. In this study, we tested the feasibility of anaesthetised fMRI in 11 patients (mean age = 9.8 years) with Lennox-Gastaut syndrome, a severe form of childhood-onset epilepsy associated with intellectual disability. fMRI was acquired during clinically-indicated MRI sessions using a synergistic anaesthesia regimen we typically administer for epilepsy ne..

View full abstract


Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (Grant Number 628725, 2010-2013). Aaron E.L. Warren was supported by an Australian Government Research Training Program Scholarship, and post-doctoral fellowship funding from the Lennox-Gastaut syndrome Foundation (www.lgsfo undation. org). David F. Abbott was supported by fellowship funding from the National Imaging Facility. Simon J. Vogrin was supported by the RCH 1000 Fund within the Developmental Imaging research group at the Murdoch Children's Research Institute and the Children's MRI Centre, The Royal Children's Hospital.