Journal article

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt

AJP Endocrinology and Metabolism | AMER PHYSIOLOGICAL SOC | Published : 2020

Abstract

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. We tested the hypothesis that human visceral adipose tissue (VAT) impairs glucose homeostasis, whereas subcutaneous glutealfemoral adipose tissue (GFAT) protects against the development of impaired glucose homeostasis in mice. VAT and GFAT were collected from patients undergoing bariatric surgery and grafted onto the epididymal adipose tissue of weight- and age-matched severe, combined immunodeficient mice. SHAM mice underwent surgery without transplant of tissue. Mice were fed a high-fat diet after xenograft. Energy homeostasis, glucose metabolism, and insulin sen..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Awarded by Victorian Cancer Agency


Funding Acknowledgements

These studies were supported by funding from National Health and Medical Research Council (NHMRC) of Australia (APP1098972). T. Tsiloulis was supported by the Australian Postgraduate Award and the Paula and Jack Hansky Ph.D. Scholarship (Monash University). M. J. Watt is supported by a Senior Research Fellowship from the NHMRC (APP1077703). R. A. Taylor is supported by a research fellowship from the Victorian Cancer Agency (MCRF15023).