Journal article
Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: Study protocol for a randomised double-blind controlled trial (BRIGhTMIND)
R Morriss, L Webster, M Abdelghani, DP Auer, S Barber, P Bates, A Blamire, PM Briley, C Brookes, S Iwabuchi, M James, C Kaylor-Hughes, S Lankappa, P Liddle, H McAllister-Williams, A O'Neill-Kerr, S Pszczolkowski Parraguez, A Suazo DI Paola, L Thomson, Y Walters
BMJ Open | BMJ PUBLISHING GROUP | Published : 2020
Abstract
Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression. Methods and analysis The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachuset..
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Funding Acknowledgements
This project (project reference 16/44/22) is funded by the Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership. Equipment for the study was provided by Magstim Company. SponsorResearch and Evidence Team, Nottinghamshire Healthcare NHS Foundation Trust. The views expressed in this publication are those of the author(s) and not necessarily those of the MRC, NIHR, Magstim Company or the Department of Health and Social Care.