Journal article

Adverse reactions to vancomycin and cross-reactivity with other antibiotics

Joseph F De Luca, Natasha E Holmes, Jason A Trubiano

Current Opinion in Allergy & Clinical Immunology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


PURPOSE OF REVIEW: Glycopeptide antibiotics such as vancomycin are frequently utilized to treat resistant Gram-positive infections such as methicillin-resistant Staphylococcus aureus. The current literature on glycopeptide and lipoglycopeptide structure, hypersensitivity and potential cross-reactivity was reviewed, highlighting implications for safe prescribing. RECENT FINDINGS: Structurally similar, glycopeptides could theoretically cross-react. Immediate reactions to vancomycin include non-IgE-mediated reactions (e.g. red man syndrome) and IgE-mediated hypersensitivity (e.g. anaphylaxis), sharing clinical features. Vancomycin can activate mast cells via MAS-related G-protein-coupled recept..

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