Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
Sean L McGee, Mark Hargreaves
Nature Reviews Endocrinology | NATURE RESEARCH | Published : 2020
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic diseases of modern society. It is well appreciated that regular exercise improves metabolism and the metabolic phenotype in a number of tissues. The phenotypic alterations observed in skeletal muscle are partly mediated by transcriptional responses that occur following each individual bout of exercise. This adaptive response increases oxidative capacity and influences the function of myokines and extracellular vesicles that signal to other tissues. Our understanding of the epigenetic and transcriptional mechanisms that mediate the skeletal muscle gene expression response to exercise as well as of thei..View full abstract
The authors acknowledge the many researchers whose work they have not been able to cite in this Review. Original work by the authors was supported by the Diabetes Australia Research Program and the National Health and Medical Research Council of Australia.