The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease

DM Bartlett; A Govus; T Rankin; A Lampit; K Feindel; G Poudel; WP Teo; J Lo; N Georgiou-Karistianis; MR Ziman; TM Cruickshank

Journal article

The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease

DM Bartlett, A Govus, T Rankin, A Lampit, K Feindel, G Poudel, WP Teo, J Lo, N Georgiou-Karistianis, MR Ziman, TM Cruickshank

Journal of the Neurological Sciences | ELSEVIER | Published : 2020

DOI: 10.1016/j.jns.2020.117022

Abstract

Background: Huntington's disease (HD) is a chronic, progressive neurodegenerative condition for which there are currently no proven disease-modifying therapies. Lifestyle factors have been shown to impact on the age of disease onset and progression of disease features. We therefore investigated the effects of a nine-month multidisciplinary rehabilitation intervention on neuroimaging, biological and clinical disease outcomes in individuals with premanifest HD. Methods: 31 individuals with premanifest HD participated in the study. Eighteen participants underwent a nine-month multidisciplinary rehabilitation intervention comprising aerobic and resistance exercise, computerised cognitive trainin..

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University of Melbourne Researchers

Amit Lampit Author

Grants

Funding Acknowledgements

This study was funded by Lotterywest (107/20090827). The authors would like to acknowledge Genesis Fitness Bentley and Kelmscott, ECU Sports and Fitness Mt. Lawley and Vario gymnasiums for in-kind use of their facilities. The authors also acknowledge the technical assistance of the Psytas Technologies, Melbourne, Australia for Neuroimaging data analyses.