The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease
Danielle M Bartlett, Andrew Govus, Timothy Rankin, Amit Lampit, Kirk Feindel, Govinda Poudel, Wei-Peng Teo, Johnny Lo, Nellie Georgiou-Karistianis, Mel R Ziman, Travis M Cruickshank
Journal of the Neurological Sciences | ELSEVIER | Published : 2020
BACKGROUND: Huntington's disease (HD) is a chronic, progressive neurodegenerative condition for which there are currently no proven disease-modifying therapies. Lifestyle factors have been shown to impact on the age of disease onset and progression of disease features. We therefore investigated the effects of a nine-month multidisciplinary rehabilitation intervention on neuroimaging, biological and clinical disease outcomes in individuals with premanifest HD. METHODS: 31 individuals with premanifest HD participated in the study. Eighteen participants underwent a nine-month multidisciplinary rehabilitation intervention comprising aerobic and resistance exercise, computerised cognitive trainin..View full abstract
Awarded by Lotterywest
This study was funded by Lotterywest (107/20090827). The authors would like to acknowledge Genesis Fitness Bentley and Kelmscott, ECU Sports and Fitness Mt. Lawley and Vario gymnasiums for in-kind use of their facilities. The authors also acknowledge the technical assistance of the Psytas Technologies, Melbourne, Australia for Neuroimaging data analyses.