Temporal Trend in Young-Onset Type 2 Diabetes-Macrovascular and Mortality Risk: Study of UK Primary Care Electronic Medical Records
Digsu N Koye, Joanna Ling, John Dibato, Kamlesh Khunti, Olga Montvida, Sanjoy K Paul
Diabetes Care | AMER DIABETES ASSOC | Published : 2020
OBJECTIVE: To evaluate temporal prevalence trend, cardiometabolic risk factors, and the risk of atherosclerotic cardiovascular disease (ASCVD) and all-cause mortality (ACM) in incident young- and usual-onset type 2 diabetes. RESEARCH DESIGN AND METHODS: From the U.K. primary care database, 370,854 people with a new diagnosis of type 2 diabetes from 2000 to 2017 were identified. Analyses were conducted by age-group (18-39, 40-49, 50-59, 60-69, 70-79 years) and high-/low-risk status without history of ASCVD at diagnosis, with subjects with two or more of current smoking, high systolic blood pressure, high LDL cholesterol (LDL-C), or chronic kidney disease classified as high risk. RESULTS: The ..View full abstract
The Melbourne EpiCentre gratefully acknowledges support from the National Health and Medical Research Council and the Australian Government's National Collaborative Research Infrastructure Strategy initiative through Therapeutic Innovation Australia.