Journal article

Temporal Trend in Young-Onset Type 2 Diabetes-Macrovascular and Mortality Risk: Study of UK Primary Care Electronic Medical Records

Digsu N Koye, Joanna Ling, John Dibato, Kamlesh Khunti, Olga Montvida, Sanjoy K Paul

Diabetes Care | AMER DIABETES ASSOC | Published : 2020


OBJECTIVE: To evaluate temporal prevalence trend, cardiometabolic risk factors, and the risk of atherosclerotic cardiovascular disease (ASCVD) and all-cause mortality (ACM) in incident young- and usual-onset type 2 diabetes. RESEARCH DESIGN AND METHODS: From the U.K. primary care database, 370,854 people with a new diagnosis of type 2 diabetes from 2000 to 2017 were identified. Analyses were conducted by age-group (18-39, 40-49, 50-59, 60-69, 70-79 years) and high-/low-risk status without history of ASCVD at diagnosis, with subjects with two or more of current smoking, high systolic blood pressure, high LDL cholesterol (LDL-C), or chronic kidney disease classified as high risk. RESULTS: The ..

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Funding Acknowledgements

The Melbourne EpiCentre gratefully acknowledges support from the National Health and Medical Research Council and the Australian Government's National Collaborative Research Infrastructure Strategy initiative through Therapeutic Innovation Australia.