Search and Contain: Impact of an integrated genomic and epidemiological surveillance and response program for control of carbapenemase-producing Enterobacterales.
Courtney R Lane, Judith Brett, Mark Schultz, Claire L Gorrie, Kerrie Stevens, Donna RM Cameron, Siobhan St George, Annaliese van Diemen, Marion Easton, Rhonda L Stuart, Michelle Sait, Anton Y Peleg, Andrew J Stewardson, Allen C Cheng, Denis W Spelman, Mary Jo Waters, Susan A Ballard, Norelle L Sherry, Deborah A Williamson, Finn Romanes Show all
Clin Infect Dis | Published : 2020
BACKGROUND: Multi-resistant organisms (MROs) pose a critical threat to public health. Population-based programs for control of MROs such as Carbapenemase-producing Enterobacterales (CPE) have emerged and evaluation is needed. We assess the feasibility and impact of a state-wide CPE surveillance and response program deployed in December 2015 across Victoria, Australia (population 6.5 million). METHODS: A prospective multi-modal intervention including active screening, carrier isolation, centralised case investigation and comparative pathogen genomics was implemented. We analyze trend in CPE incidence and clinical presentation, risk factors and local transmission over the program's first three..View full abstract