Journal article

Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

CheukMan C Au, John B Furness, Kara Britt, Sofya Oshchepkova, Heta Ladumor, Kai Ying Soo, Brid Callaghan, Celine Gerard, Giorgio Inghirami, Vivek Mittal, Yufeng Wang, Xin Yun Huang, Jason A Spector, Eleni Andreopoulou, Paul Zumbo, Doron Betel, Lukas Dow, Kristy A Brown

eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020

Abstract

Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second leading cause of cancer-related death. Despite extensive research relating to the hormone ghrelin, responsible for the stimulation of growth hormone release and appetite, little is known of the effects of its unacylated form, especially in cancer. The present study aimed to characterize effects of unacylated ghrelin on breast cancer cells, define its mechanism of action, and explore the therapeutic potential of unacylated ghrelin or analog AZP-531. We report potent anti-tumor effects of unacylated ghrelin, dependent on cells being cultured in 3D in a biologically-re..

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Grants

Awarded by National Breast Cancer Foundation


Awarded by National Health and Medical Research Council


Funding Acknowledgements

National Breast Cancer Foundation NC-14-011 Kristy A Brownr State Government of Victoria Kristy A Brownr National Health and Medical Research Council GNT1007714 Kristy A Brownr The Endocrine Society of Australia Kristy A Brownr National Breast Cancer Foundation ECF-16-004 Kristy A Brownr National Breast Cancer Foundation Kara Brittr The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.