Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus
Aya C Taki, Robert Brkljaca, Tao Wang, Anson Koehler, Guangxu Ma, Jill Danne, Sarah Ellis, Andreas Hofmann, Bill CH Chang, Abdul Jabbar, Sylvia Urban, Robin B Gasser
PATHOGENS | MDPI | Published : 2020
Eight secondary metabolites (1 to 8) were isolated from a marine sponge, a marine alga and three terrestrial plants collected in Australia and subsequently chemically characterised. Here, these natural product-derived compounds were screened for in vitro-anthelmintic activity against the larvae and adult stages of Haemonchus contortus (barber's pole worm)-a highly pathogenic parasitic nematode of ruminants. Using an optimised, whole-organism screening system, compounds were tested on exsheathed third-stage larvae (xL3s) and fourth-stage larvae (L4s). Anthelmintic activity was initially evaluated on these stages based on the inhibition of motility, development and/or changes in morphology (ph..View full abstract
This study was supported by an Australian Postgraduate Research Award for Robert Brklja.ca (S.U.), and Yourgene Health Singapore Pte Ltd. and the Australian Research Council (ARC) (R.B.G., A.V.K. and A.J.).